Version 1.3.2 corrects internal version-number labeling errors present in Version 1.3.1. No scientific content, figures, or interpretations have been changed. This update ensures internal consistency between the manuscript version number and Zenodo record. Version 1.3.1 includes an orientation model (Compass of Coherence) illustrating the spatial regulatory organization of this axis. It does not introduce new biological mechanisms. Instead, it provides a structural interpretation clarifying how established regulatory components function together as a continuous physiological axis connecting upstream metabolic signaling, renal execution, and downstream electrolyte outcomes. Positioning the kidney as the primary integration and execution interface highlights how renal nitric oxide production, vascular tone regulation, and renin–angiotensin signaling translate upstream receptor activity into electrolyte transport decisions. This orientation framework is interpretive and hypothesis-generating. It is intended to complement established physiology by providing a structural basis for understanding state-dependent divergence in chloride homeostasis and acid–base balance, including hyperchloremic non–anion gap metabolic acidosis phenotypes. This mechanistic note is part of an ongoing mechanistic continuity series examining bile acid–RAAS–electrolyte regulatory interactions.
Beth Martell (2026) studied this question.