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February 27, 20260 citations

Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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KTKavalipurapu Venkata TejaKVKaligotla Apoorva VasundharaRPRomeo Patini

Key Points

  • The study aims to evaluate the impact of different sodium hypochlorite concentrations on post-endodontic pain.
  • Conducted a systematic review and meta-analysis of randomized controlled trials.
  • Compared the effects of high and low sodium hypochlorite concentrations on post-endodontic pain incidence.
  • Evaluated pain outcomes using standardized methodologies across studies.
  • No significant differences in post-endodontic pain between high and low sodium hypochlorite concentrations were found.
  • Concentrations below 5% may be associated with a lower incidence of pain.
  • Call for further well-designed trials to confirm findings.

Abstract

Within the limitations of the present study, no significant differences in post-endodontic pain were found between high and low NaOCl concentrations. However, concentrations < 5% might be associated with less pain incidence. Further well-designed clinical trials with standardized methodologies are needed to provide more conclusive evidence.

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Cite This Study

Teja et al. (2026) studied this question.

synapsesocial.com/papers/69a1357fed1d949a99abf6achttps://doi.org/10.1002/cre2.70320
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