Affective temperament profiles in patients with herpes zoster and postherpetic neuralgia: a comparative analysis using TEMPS-A scale

Introduction This study aimed to compare affective temperament profiles between HZ and Q5 PHN patients and examine relationships among temperaments, pain intensity, quality of life, depression, and anxiety. Method This prospective, cross-sectional study included 70 participants (35 HZ, 35 PHN) recruited from a university pain clinic. Affective temperaments were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-questionnaire (TEMPS-A). Additional measures included the Hospital Anxiety and Depression Scale (HADS), Neuropathic Pain Impact on Quality-of-Life Questionnaire (NePIQoL), and Visual Analog Scale (VAS) for pain. Results PHN patients were significantly older than HZ patients (69.31 ± 6.16 vs. 63.40 ± 9.36 years, p=0.003). Significant differences emerged across all temperament domains (p0.001). HZ patients demonstrated predominant hyperthymic temperament (12.86 ± 3.99), while PHN patients exhibited primarily anxious temperament (16.03 ± 4.81). PHN patients showed significantly higher depressive, cyclothymic, irritable, and anxious temperament scores with large effect sizes (Cohen’s d: -0.686 to -1.456). Depression, anxiety, and quality of life measures were significantly worse in PHN patients. Strong correlations were observed between temperament dimensions and pain intensity, particularly in PHN patients (r=-0.940 to 0.934), and between temperaments and psychological measures. Discussion Distinct affective temperament profiles differentiate acute HZ from chronic PHN patients, suggesting temperamental factors may influence pain persistence and psychological outcomes. These findings support incorporating temperament assessment into clinical evaluation for risk stratification and personalized pain management strategies.