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February 28, 2026PharmaceuticalsOpen Access

Optimization of Thyme, Cinnamon, and Black Seed Oil Combinations for Enhanced Antibacterial and Antioxidant Efficacy: Mixture Design and In Silico Insights

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Authors

MMMahmoud S. MaherDADina A. AltwileyDADalal M. Alkuraythi

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Overview

Demonstrates enhanced antibacterial and antioxidant effects of optimized oil combinations, suggesting potential therapeutic applications.

Key Points

  • This research aimed to optimize the antibacterial and antioxidant efficacy of thyme, cinnamon, and black seed oil combinations using systematic design approaches.
  • Applied Augmented Simplex Centroid Mixture Design to evaluate oil combinations.
  • Assessed antibacterial activity by determining minimum inhibitory concentrations against E. coli and S. aureus.
  • Measured antioxidant activity using DPPH radical scavenging assay (IC50).
  • Conducted molecular docking and ADMET predictions to support findings.
  • Optimal mixture found to be 41.7% thyme, 41.7% cinnamon, and 16.7% black seed oil.
  • Achieved MIC values of 0.5 µL/mL for E. coli and 0.517 µL/mL for S. aureus.
  • DPPH IC50 value was 5.32 ± 0.52 mg/mL.
  • Synergistic interactions confirmed by checkerboard assays with ΣFIC values of 0.15 and 0.29.

Cite This Study

Maher et al. (2026) studied this question.

synapsesocial.com/papers/69a286720a974eb0d3c01597https://doi.org/10.3390/ph19030372
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  5. 5Thyme and cinnamon essential oils inhibit multidrug resistant Escherichia coli and Klebsiella pneumoniae and alter virulence transcripts2026 · 3 citations