The Ritter reaction of 2-(2-methoxyphenyl)-1-methylcyclohexan-1-ols with various nitriles was investigated. Depending on the nature of the nitrile and the substituents on the 2-methoxyphenyl fragment of the alcohols, the reaction can lead to both -(2-(2-methoxyphenyl)-1-methylcyclohexyl)amides and derivatives of partially hydrogenated spiroindolenines in a diastereoselective manner.
Y.S. Rozhkova (Wed,) studied this question.