An Implementation Science Study of a Community-Based PrEP Navigation Intervention for Men in South Florida.

Preexposure prophylaxis (PrEP) is effective for HIV prevention, yet PrEP-eligible men face structural, social, and cultural barriers to access. In this implementation science study, we evaluated a community-tailored PrEP navigation program to identify modifiable factors influencing adoption and implementation. Using staff interviews and participatory Photovoice with clients, we uncovered multilevel barriers to and facilitators of PrEP uptake. Findings were shared with a community-based organization to inform program improvements. This study highlights the value of participatory, implementation-focused approaches to equitable HIV prevention. (Am J Public Health. 2026;116(S1):S28-S31. https://doi.org/10.2105/AJPH.2025.308344).