Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation

Key Points

• This research aims to explore how circular RNAs (circRNAs) are regulated by ionizing radiation in triple-negative breast cancer cells.
• Analyzed circRNA expression patterns in different cell lines exposed to ionizing radiation.
• Assessed time- and dose-dependent changes in circRNA levels.
• Performed pathway enrichment analysis to identify potential applications of circRNAs.
• Identified distinct circRNA expression patterns specific to cell lines under radiation.
• Highlighted circRNAs as potential biomarkers for radiation sensitivity.
• Proposed circRNAs as therapeutic targets to improve treatment outcomes in TNBC.