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February 28, 2026Proceedings of the National Academy of SciencesOpen Access

The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry

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Authors

MLMadison LoveRDRichard C. DangJXJian Xie

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Overview

Reveals Rabankyrin-5 mediates endosomal fusion in human papillomavirus entry, indicating a role in viral infection mechanisms.

Key Points

  • Investigate the role of Rabankyrin-5 in endosomal fusion during human papillomavirus entry.
  • Identified Rabankyrin-5 as a Rab5 effector involved in endosomal processes.
  • Examined its interaction with HPV minor capsid protein L2 and dynein motor complex.
  • Analyzed the impact of Rabankyrin-5 on endosomal fusion and virus transport along microtubules.
  • Rabankyrin-5 is essential for the fusion of HPV-carrying endosomes during entry.
  • It acts as a dynein adaptor, linking the HPV minor capsid protein L2 and dynein motor complex.
  • Facilitates virus movement along microtubules, supporting early viral entry.

Cite This Study

Love et al. (2026) studied this question.

synapsesocial.com/papers/69a287240a974eb0d3c029aahttps://doi.org/10.1073/pnas.2524765123
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