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Herpes Zoster and Frailty in Older Adults: a Systematic Review. | Synapse

February 28, 2026Open Access

Herpes Zoster and Frailty in Older Adults: a Systematic Review.

Key Points

The research aims to explore the relationship between frailty and herpes zoster in older adults.
Conducted a systematic review of existing literature on herpes zoster and frailty
Assessed the impact of frailty on vaccine uptake and prevention of herpes zoster
Identified gaps in longitudinal studies and standardized measures of frailty
Frailty increases the vulnerability to herpes zoster and postherpetic neuralgia (PHN)
Routine frailty assessment may enhance vaccine uptake in older adults
There is a need for further studies to understand causal pathways

Abstract

Frailty may increase vulnerability to HZ and PHN. Routine frailty assessment may improve vaccine uptake and prevention. Further longitudinal studies using standardized frailty measures are needed to understand the causal pathways and optimize care.

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Cite This Study

D'Elia et al. (Sun,) studied this question.

synapsesocial.com/papers/69a287240a974eb0d3c02abc https://doi.org/https://doi.org/10.5770/cgj.29.916