Lysozyme as an amyloid fibril protein together with transthyretin in the ligamentum flavum in association with lumbar spinal stenosis.

Key Points

• The aim is to investigate the role of lysozyme alongside transthyretin in amyloid fibrils associated with lumbar spinal stenosis.
• Analysis of amyloid deposits in ligamentum flavum samples from lumbar spinal stenosis cases
• Comparison of ATTR amyloid and lysozyme deposits
• Identification of intermixing patterns of amyloid proteins
• ATTR amyloid deposits are the most common in lumbar spinal stenosis
• Lysozyme amyloid deposits are frequently found intermixed with ATTR deposits
• The presence of both amyloid types suggests a complex pathophysiology in lumbar spinal stenosis