What question did this study set out to answer?

To synthesize derivatives of 5-cyano-2-methyl-dihydropyridine through multicomponent reactions.

February 28, 2026

Method for Producing 5-Cyano-2-Methyl--(2-Methylphenyl)-4-(4-Nitrophenyl)-6-Thioxo-1,6-Dihydropyridine-3-Carboxamide Derivatives

Key Points

To synthesize derivatives of 5-cyano-2-methyl-dihydropyridine through multicomponent reactions.
Utilized multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, and alkyl halides.
Conducted reactions by boiling in ethanol with potassium hydroxide as a catalyst.
Employed specific ratios of reactants to optimize product yield.
Achieved yields of 64–91% for the target thioxo-dihydropyridine derivatives.
Synthesized 2-alkylthiopyridines and 3-aminothieno[2,3-]pyridines as key products.

Abstract

The multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, -(2-methylphenyl)-3-oxobutanamide and alkyl halides upon boiling in ethanol in the presence of twice the amount of potassium hydroxide produced derivatives of 5-cyano-2-methyl--(2-methylphenyl)-4-(4-nitrophenyl)-6-thioxo-1,6-dihydropyridine-3-carboxamide – 2-alkylthiopyridines and 3-aminothieno2,3-pyridines, with yields of 64–91%.

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B.S. Krivokolysko (Wed,) studied this question.

www.synapsesocial.com/papers/69a287a00a974eb0d3c037f2 — DOI: https://doi.org/10.7868/s3034630425110092

Method for Producing 5-Cyano-2-Methyl--(2-Methylphenyl)-4-(4-Nitrophenyl)-6-Thioxo-1,6-Dihydropyridine-3-Carboxamide Derivatives

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