Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling

Key Points

• The research aims to explore how dietary anthocyanins can reduce age-related hepatic steatosis through gut microbiota modulation.
• Administered dietary anthocyanins, specifically Cy-3-G, to promote gut microbiota expansion.
• Assessed the changes in bile acid composition post-intervention.
• Evaluated activation of hepatic FXR signaling pathways.
• Cy-3-G significantly expanded L. reuteri in the gut microbiota.
• Bile acid composition shifted toward a more favorable profile.
• Activated hepatic FXR signaling was linked to the reduction of hepatic steatosis.

Abstract