What does this research mean for the field?

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy through the HuR/TRIM26/NR4A1 signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore how P2X7R deficiency affects cardiac ageing, focusing on the role of the HuR/TRIM26/NR4A1 axis.

February 28, 2026

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.

Key Points

This research aims to explore how P2X7R deficiency affects cardiac ageing, focusing on the role of the HuR/TRIM26/NR4A1 axis.
Investigated the effects of P2X7R deficiency on cardiac tissues.
Analyzed mitophagy markers related to cellular aging.
Examined the HuR/TRIM26/NR4A1 signalling pathway for its regulatory role.
P2X7R deficiency significantly enhances mitophagy in cardiac tissues.
Activation of the HuR/TRIM26/NR4A1 axis is identified as crucial in improving cardiac health.
Findings suggest a potential therapeutic target for cardiac ageing.

Abstract

Our findings provide valuable insights into the role of P2X7R in cardiac ageing and identify the HuR/TRIM26/NR4A1 axis as a key signalling pathway through which P2X7R regulates cardiac ageing.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Yixin Zhou

Xin Zhong

Zhijie Mao

Actions

Institutions

Shanghai Jiao Tong University

Wenzhou Medical University

Ruijin Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study