Mn(III)-mediated oxidative cyclisation via C(sp³)-H functionalisation: An efficient strategy for benzo-fused aza-heterocycle synthesis

Key Points

• To develop an efficient methodology for synthesizing benzo-fused aza-heterocycles via C(sp³)-H functionalisation.
• Utilized Mn(III) as a catalyst for C(sp³)-H functionalisation.
• Involved alicyclic amines and malonate in the synthesis process.
• Focused on the intramolecular coupling to form six- to nine-membered rings.
• Successfully produced various benzo-fused aza-heterocycles.
• Demonstrated high efficiency in the cyclisation process.
• Synthesis yielded notable improvements in product formation compared to traditional methods.