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February 28, 2026Atlas Universitesi Tip ve Saglik Bilimleri Dergisi

The Relationship Between Plasma Fibrinogen Levels and Mortality in Patients with Sepsis Followed in the Intensive Care Unit

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Authors

OİOKTAY İNANEİEZGİ AYDIN İNANETEngin İhsan Turan

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Overview

This retrospective study identifies the impact of fibrinogen levels on mortality in sepsis patients, suggesting clinical implications for prognosis.

Key Points

  • This research aims to investigate the relationship between plasma fibrinogen levels and mortality in sepsis patients in the ICU.
  • Retrospective analysis of 80 patients aged 18-90 with sepsis in an ICU.
  • Measurement of fibrinogen, platelet, WBC, INR, aPTT, CRP, and procalcitonin on days 0 and 3.
  • Comparison of SOFA and ISTH scores with mortality outcomes.
  • Statistical analysis using SPSS 22.0.
  • Lower fibrinogen levels correlate with higher SOFA and ISTH scores (p values: SOFA p:0.032, p:0.005; ISTH p:0.026, p:0.038).
  • High laboratory values for WBC, Platelet, Procalcitonin, and D-Dimer in low fibrinogen group (p values ranging from 0.001 to 0.030).
  • Mortality is significantly higher in the low fibrinogen group compared to others (p<0.001).

Cite This Study

İNAN et al. (2026) studied this question.

synapsesocial.com/papers/69a287f20a974eb0d3c03ca9https://doi.org/10.54270/atljm.2026.102
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