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February 28, 2026Disease Models & Mechanisms0 citationsOpen Access

First person – Tabea Soelter and Emma Jones

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Key Points

  • This research aims to uncover the role of cell-type-specific alternative splicing in neurodegenerative and psychiatric disorders.
  • Conducted interviews with the first authors of selected papers.
  • Used transcriptomics and bioinformatics techniques.
  • Focused on specific mouse models, particularly Setbp1S858R Schinzel–Giedion syndrome.
  • Identified mechanisms underlying age-associated diseases in the brain and kidney.
  • Discovered links between alternative splicing and disease phenotype in specific tissues.

Abstract

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Tabea Soelter and Emma Jones are co-first authors on ‘ Cell-type-specific alternative splicing in the brain and kidney of a Setbp1S858R Schinzel–Giedion syndrome mouse’, published in DMM. Tabea is a computational biologist in the lab of Brittany Lasseigne at The University of Alabama at Birmingham, Birmingham, AL, USA, using transcriptomics and bioinformatics to uncover the mechanisms underlying age-associated diseases, specifically those with a neurodegenerative phenotype. Emma conducted the research described in this article while a PhD student in Brittany Lasseigne's lab at The University of Alabama at Birmingham. She is now a postdoc in the lab of Joseph Dougherty at Washington University in St Louis, St Louis, MO, USA, using transcriptomics to understand the mechanisms underlying neurodevelopmental and psychiatric disorders.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/69a288170a974eb0d3c04171https://doi.org/10.1242/dmm.052868
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