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February 28, 2026Chemical Science0 citationsOpen Access

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

YCYing ChenQMQing MengHXHao Xiang

Key Points

  • The research aims to identify new antibacterial lipopeptides by focusing on the role of lipid donors in their structure.
  • Utilized genome mining techniques to isolate lipopeptide structures.
  • Analyzed the chemical composition of lipid tails in antibiotic candidates.
  • Prioritized lipid donor-associated compounds during screening.
  • Identified dioxanopeptins as new lipopeptide antibiotics.
  • Demonstrated that lipid tail structures significantly enhance antibacterial activity.
  • Showed potential for discovering novel antibiotics through lipid donor focus.

Abstract

Non-ribosomal lipopeptide antibiotics derive much of their antibacterial performance from the structure of their lipid tail, yet genome mining remains largely peptide-centric and rarely prioritizes lipid donor formation as an...

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a288590a974eb0d3c042c7https://doi.org/10.1039/d6sc00003g
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