Access to Substituted Pyrimidines via Isoxazole Ring Transformation in Three-Component Reactions with Amines and Orthoesters

Key Points

• This research aims to explore the synthesis of substituted pyrimidines through isoxazole ring transformation.
• Synthesis of pyrimidines via three-component reactions of 5-aminoisoxazole-4-carbonitrile, primary amines, and orthoesters.
• Utilized both microwave and conventional heating methods for the reaction.
• The one-pot rearrangement of products was conducted without the need for chromatography.
• The method successfully synthesizes a variety of pyrimidines efficiently at a gram scale.
• The reaction resulted in expanded structural diversity of the synthesized compounds.

Abstract