Polysubstituted bicyclo-2.1.1-hexanes as benzene isosteres for medicinal chemistry | Synapse
March 1, 2026
Polysubstituted bicyclo-2.1.1-hexanes as benzene isosteres for medicinal chemistry
Puntos clave
The review aims to summarize and analyze recent methodologies for synthesizing bicyclo[2.1.1]hexane derivatives.
Reviewed literature from 2020 to early 2025
Organized synthesis methods by mechanisms
Classified exit vectors achieved during synthesis
Identified various methodologies for bicyclo[2.1.1]hexane synthesis
Showcased potential applications in medicinal chemistry
Highlighted importance of benzene isosteres in drug design
Resumen
This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo2.1.1hexane derivatives, organised by mechanisms and the exit vectors achieved.