Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR-F508del Rabbit Model.

Puntos clave

• The research aims to explore features of cystic fibrosis carriers using a specific rabbit model.
• Utilized heterozygous ΔF508 CF rabbits as a model.
• Examined sinonasal characteristics related to cystic fibrosis carriers.
• Assessed CFTR function and infection clearance capabilities.
• Demonstrated reduced CFTR function in the CF rabbit model.
• Showed altered host defense mechanisms in the model.
• Highlighted impaired infection clearance in the sinonasal system.