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March 2, 2026The Journal of Headache and Pain0 citationsOpen Access

Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map with selective meta-analyses

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RCRocco Salvatore CalabròACAndrea CalderoneLBLilla Bonanno

Key Points

  • The aim is to evaluate advanced pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions using an evidence map and meta-analyses.
  • Conducted a systematic evidence map of interventions for orofacial pain.
  • Performed selective meta-analyses to assess the efficacy of treatments.
  • Analyzed short-term and long-term effects and outcomes of treatments.
  • Photobiomodulation/low-level laser therapy (PBM/LLLT) showed significant short-term pain relief compared to inactive control.
  • Transportability of findings is uncertain due to null-crossing prediction intervals.
  • Limited long-term data suggests need for more comprehensive trials.

Abstract

PBM/LLLT shows the clearest short-term analgesic signal for BMS versus inactive control, but transportability remains uncertain given null-crossing prediction intervals and limited long-term data. Future trials should standardize outcomes, extend follow-up, and report harms transparently to support diagnosis-stratified care.

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Cite This Study

Calabrò et al. (2026) studied this question.

synapsesocial.com/papers/69a52de5f1e85e5c73bf1134https://doi.org/10.1186/s10194-026-02300-7
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