The P2Y12 i-T744C polymorphism was associated with a significantly increased risk of large-artery atherosclerosis stroke with adjusted OR 2.024 (p=0.009) in the dominant model.
Case-Control (n=649)
No
Does the P2Y12 i-T744C polymorphism increase the risk of specific ischemic stroke subtypes in adults?
The P2Y12 i-T744C polymorphism is an independent risk factor for large-artery atherosclerosis stroke and improves risk prediction when integrated with clinical variables.
Estimación del efecto: Adjusted OR 2.024 for dominant model; Adjusted OR 1.703 for additive model (95% CI 95% CI 1.191–3.440 for dominant model; 95% CI 1.078–2.692 for additive model)
Tasa de eventos absoluta: 21.5% vs 12.9%
valor p: p=0.009 for dominant model; 0.023 for additive model
The P2Y12 i-T744C polymorphism may serve as a predictor for LAA stroke. Furthermore, we constructed a genomic-clinical nomogram that may be valuable for predicting LAA stroke risk in the study population.
Wu et al. (Fri,) conducted a case-control in Adults (≥18 years) with first-ever acute ischemic stroke classified into large-artery atherosclerosis (LAA), small-vessel occlusion (SVO), or cardioembolism (CE) subtypes based on TOAST criteria, admitted within 1 week of symptom onset (n=649). P2Y12 i-T744C polymorphism presence vs. Non-carriers of P2Y12 i-T744C polymorphism (TT genotype) was evaluated on Association of P2Y12 i-T744C polymorphism with susceptibility to LAA stroke (Adjusted OR 2.024 for dominant model; Adjusted OR 1.703 for additive model, 95% CI 95% CI 1.191–3.440 for dominant model; 95% CI 1.078–2.692 for additive model, p=0.009 for dominant model; 0.023 for additive model). The P2Y12 i-T744C polymorphism was associated with a significantly increased risk of large-artery atherosclerosis stroke with adjusted OR 2.024 (p=0.009) in the dominant model.