Abstract Objectives To investigate how phase composition influences the physicochemical properties, Sr 2+ ion release behavior, and cytocompatibility of Strontium (Sr)-doped calcium phosphate (CaP) materials, focusing on Sr-HA, Sr- β -TCP, and three Sr-BCP compositions. Methods This work focuses on Sr-HA, Sr- β -TCP, and Sr-BCP powders with HA/ β -TCP ratios (60:40 (BCP1), 30:70 (BCP2), and 20:80 (BCP3)) that were synthesized by wet chemical precipitation followed by calcination. The effect of CaP phase compositions on physicochemical characteristics, Sr 2+ release, and cytocompatibility was investigated by using ICP-OES, FTIR, XRD, SEM-EDX, and MTT assays. Results EDX confirmed the Ca/P ratios, and both FTIR and XRD indicated successful phase formation without secondary phases. The Sr-BCP samples demonstrated enhanced cell viability after 48 h in MTT assays, highlighting biological responses associated with the biphasic structure. ICP-OES analysis indicated composition-dependent Sr 2+ release, with Sr-BCP1 showing the highest initial and sustained ion release. Conclusions Sr-BCP1 offers a promising balance between structural stability, favorable cytocompatibility, and controlled Sr 2+ ion delivery, supporting its potential for bone applications.
Marathandi et al. (Sat,) studied this question.