Metformin use and reduced dementia risk in older adults with type 2 diabetes and delirium

Key Points

• Dementia risk is significantly lower among older adults taking metformin compared to those not using it, indicating a potential neuroprotective effect.
• Data from a cohort of older adults with type 2 diabetes and delirium show that metformin users have a marked reduction in dementia incidence over time.
• Observational analysis identifies cognitive function improvements linked with metformin use through various neurological pathways and biomarkers.
• This finding supports the need for further research into metformin's cognitive benefits in diverse populations with type 2 diabetes and related conditions.