Sevoflurane alters α5β3GABAA receptor trafficking via calcium/calmodulin-dependent protein kinase II-dependent β3 subunit phosphorylation to produce cognitive impairment in aged mice

Key Points

• Cognitive impairment arises from altered GABAA receptor trafficking, highlighting a critical connection.
• Sevoflurane exposure shows a significant impact on β3 subunit phosphorylation, influencing receptor behavior.
• Assessment using an aged mouse model demonstrates how calcium/calmodulin-dependent protein kinase plays a role.
• Understanding these mechanisms may lead to further exploration of cognitive effects of anesthesia on aging.