Comparative mRNA expression analysis confirms that a short preoperative course of aromatase inhibitors induces a more potent and uniform molecular response, characterized by profound suppression of proliferation and complete inhibition of estrogen-dependent signaling. Tamoxifen therapy is also effective but results in less pronounced suppression of key targets and, crucially, may be accompanied by early activation of the MYC oncogene, a potential marker for resistance development.
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V.V. Kometova
O.V. Burmenskaya
D.Yu. Trofimov
Russian Journal of Archive of Pathology
Research Institute of Human Morphology
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
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Kometova et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69a75a67c6e9836116a202a1 — DOI: https://doi.org/10.17116/patol20268801135