March 3, 2026Open Access

Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease

Key Points

Discriminative performance improved significantly when using both OCT and OCT angiography metrics.
Integration of these two imaging modalities enhances the detection of structural and vascular changes.
Assessment of OCT and OCTA measures demonstrates complementary value in identifying cognitive impairment nuances.
Results highlight the need for integrated imaging approaches for effective diagnosis of Alzheimer's disease.

Abstract

Integrating OCT- and OCTA-derived metrics significantly improved discriminative performance compared with either modality alone, underscoring their complementary value in capturing distinct structural and vascular alterations associated with cognitive impairment.

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Cite this study

Chua et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69a75a89c6e9836116a207dd — DOI: https://doi.org/10.1186/s13195-026-01955-3

Authors

Jacqueline Chua

Suman Singh

Shiyuan Gong

Journals

SHILAP Revista de lepidopterología

Alzheimer s Research & Therapy

Actions

Institutions

National University of Singapore

Tsinghua University

Nanyang Technological University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion