Can patient-specific lumped-parameter models quantify vessel-specific remodeling and predict right ventricular function in pulmonary hypertension?
Patients with pulmonary hypertension (PH)
Patient-specific lumped-parameter computational model
Quantification of vessel-specific remodeling and simulation of right ventricular (RV) pressure-volume dynamicssurrogate
Computational lumped-parameter models show potential as noninvasive, clinically feasible tools for assessing pulmonary vascular remodeling and right ventricular function in pulmonary hypertension.
Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.
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Lechuga et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69a75a9ec6e9836116a20aef — DOI: https://doi.org/10.1002/cph4.70102
Christopher G. Lechuga
Amirreza Kachabi
Mitchel J. Colebank
Comprehensive physiology
University of Wisconsin–Madison
University of South Carolina
Edwards Lifesciences (United States)
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