Cascade Photofragmentation/Photoalkylation for the Synthesis of α-Tertiary Alkyl Primary Amines

Key Points

• This cascade synthesis effectively produces α-quaternary primary amines through n-h imine intermediates, showcasing a novel approach.
• The method employs an efficient aza-norrish type ii fragmentation and subsequent photoalkylation under mild UV photocatalysis conditions.
• One-pot reactions allow for the use of bench-stable phenacylamines, enhancing practical applications in organic chemistry.
• Findings highlight the utility of photofragmentation, which remains relatively underexplored in synthesizing complex organic molecules.

Abstract