Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Key Points

• Innate and adaptive immune responses were activated in Microtus fortis at 10 dpi, contrasting with Kunming mice.
• The analysis reveals a distinct transcriptome profile of immune cells during infection progression at 10 dpi.
• Single-cell RNA-sequencing of peripheral blood mononuclear cells allows insight into immune dynamics in detail.
• This study highlights key differences between rodent models, which may inform future research on immunity.

Abstract