Noninvasive prediction of operational tolerance in liver transplantation based on a peripheral blood transcriptional biomarker panel

Key Points

• Operational tolerance can be predicted noninvasively using a biomarker panel, indicating promising advances in liver transplantation.
• Key evidence includes the potential for safely achieving immunosuppressive (IS) therapy withdrawal in liver transplant recipients.
• Assessment utilized a peripheral blood transcriptional biomarker panel to identify the propensity for spontaneous operational tolerance.
• The findings support a shift towards noninvasive methods, but external validation is necessary to confirm accuracy and reliability.

Abstract