Intestinal epithelial AhR deletion aggravates DSS-induced colitis via lipid- and amino-acid metabolic reprogramming: integrated metabolomic-transcriptomic evidence

Key Points

• The metabolism of lipids and amino acids is significantly altered in the absence of AhR.
• Deletion of the aryl hydrocarbon receptor in intestinal epithelial cells complicates DSS-induced colitis.
• Integrated metabolomic and transcriptomic analyses provide key evidence of these metabolic shifts.
• Highlights the necessity for further research on targeting metabolic pathways in inflammatory bowel disease.