March 3, 2026Open Access

Brain-Derived Neurotrophic Factor (BDNF) Regulation by Gut Microbiota for Anti-Aging

Puntos clave

Enhanced BDNF expression with gut microbiota interventions may lead to better cognitive function,
Evidence indicates probiotic supplementation positively influences BDNF levels in various studies,
This review incorporates findings from both animal studies and clinical trials addressing aging,
Restoring microbial balance shows potential in alleviating symptoms of mood disorders and neurodegenerative conditions.

Resumen

Gut microbiota plays a critical role in regulating brain-derived neurotrophic factor (BDNF), thereby contributing to healthy aging and the improvement of neurodegenerative and neuropsychiatric disorders. This review explores the interactions among gut microbiota, BDNF, and aging within the Gut-Brain Axis framework. Evidence from animal and clinical studies indicates that probiotic supplementation and restoration of microbial balance enhance BDNF expression, improve cognitive function, and alleviate symptoms of depression, anxiety, Alzheimer

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