Bisphosphonate treatment for secondary osteoporosis in children, youth, and young adults: a systematic review and meta-analysis

Key Points

• Bisphosphonate treatment leads to improved bone mineral density in young individuals with secondary osteoporosis, especially in adolescents.
• The meta-analysis reviewed 15 studies, highlighting a significant increase in bone health metrics and moderate risk of adverse events.
• Systematic review and meta-analysis of existing literature demonstrate the potential benefits of bisphosphonates in treating osteoporosis in children and young adults.
• Long-term effects remain uncertain, indicating a need for additional studies to evaluate safety and efficacy in diverse populations.