Integrated immune responses in Manila clam: Antimicrobial activity, immune-related enzymes activity and gene expression profiles following Vibrio anguillarum challenge

Key Points

• Enhanced antimicrobial activity observed after vibrio anguillarum challenge indicates strong immune response.
• Elevated levels of immune-related enzymes support the clam's defense mechanisms following infection.
• Gene expression profiles show significant changes, reflecting intermediate to long-term adaptive immune strategies.
• Adaptations may enable Manila clams to better cope with Vibrio infections in their natural aquatic environment.