Mechanistic and Synthetic Advances in Barton–Kellogg Olefination(2021–2025)

Abstract:: Over the past few decades, the Barton-Kellogg olefination reaction has emerged as a crucial C–C connective technique utilized in synthesizing overcrowded alkenes. The reaction has good stereoselectivity and has an enduring relevance due to the scope of its integration into complex molecule synthesis and material science applications. This review examines the developments in Barton- Kellogg olefination between 2021 and 2025, highlighting significant advances in mechanistic understanding, reaction conditions, substrate scope, and methodology. Recent developments, including the creation of asymmetric versions, gentler reaction protocols, and innovative catalyst systems, have enhanced the synthetic value of this reaction. Additionally, this review summarizes recent research on computational studies related to the mechanism and kinetics of the response, in relation to the present challenges and possible future paths for synthetic organic chemistry researchers.