Clinical relevance and mechanistic investigation of miR-1908-5p as a prognostic biomarker in colorectal cancer

Key Points

• Downregulation of miR-1908-5p correlates with advanced TNM stage and poor survival in CRC.
• CA19-9 levels are elevated alongside decreased miR-1908-5p, showing a significant relationship.
• The study highlights miR-1908-5p's role in suppressing CRC cell proliferation and invasion via SCAMP4 targeting.
• The findings suggest that miR-1908-5p could serve as a valuable prognostic biomarker for colorectal cancer.] May enable better prognostic assessments in CRC, calling for further investigation into its clinical application.

Abstract