Structural Insights into Ligand-Induced Conformational Changes in Adenine Phosphoribosyl Transferase from Fusobacterium nucleatum

Key Points

• Distinct ligand-binding modes were observed in AMP-PO4-bound FnAPRT compared to its close homolog.
• The binding structure indicates significant ligand movement during bacterial APRT reactions, affecting function and efficiency.
• Assessment of ligand-induced conformational changes revealed insights into the structural dynamics of FnAPRT.
• These findings may enable deeper understanding of enzyme mechanisms and potential targets for antibacterial strategies.

Abstract