Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies

Key Points

• Diagnostic performance of the α-synuclein seed amplification assay varies significantly among laboratories.
• The accuracy rate for distinguishing dementia with Lewy bodies from healthy controls is inconsistent.
• Assessment conducted across four laboratories to evaluate the performance of CSF α-synuclein SAA.
• Findings highlight the need for standardized procedures in diagnostic tests for DLB to enhance reliability.

Abstract