Does the integration of genetic (AF PRS) and biomarker (cystatin C) information improve the prediction of sick sinus syndrome incidence compared to sociodemographic and clinical risk factors alone?
UK Biobank participants
Integration of genetic (AF PRS) and biomarker (cystatin C) information
Sociodemographic and clinical risk factors alone
Incidence of sick sinus syndrome (SSS)hard clinical
Integrating genetic (AF PRS) and biomarker (cystatin C) information modestly improves the prediction of sick sinus syndrome incidence.
In addition to sociodemographic and clinical risk factors, AF PRS and cystatin C were linked to the SSS incidence. Although their inclusion modestly improved prediction, these findings highlighted the potential of integrating genetic and biomarker information for comprehensive SSS risk assessments.
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Hong-Ju Kim
Pil-Sung Yang
Hanjin Park
Heart
Yonsei University
Catholic University of Daegu
Yeungnam University Medical Center
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Kim et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69a75bb0c6e9836116a2379d — DOI: https://doi.org/10.1136/heartjnl-2025-327272