Circulating Mitochondrial Transfer Carrying Dihydroorotate Dehydrogenase Reduces Oxidative Cell Death in Prolonged Cold-induced Cardiac Reperfusion Injury in Heart Transplantation

Key Points

• Oxidative cell death is significantly reduced through mitochondrial transfer, indicating better preservation of graft function.
• The key intervention involved dihydroorotate dehydrogenase, which supports mitochondrial activity and suppresses ferroptosis.
• Assessment using mitochondrial transfer in heart transplantation demonstrates low risk for graft function impairment post-operation.
• This strategy highlights potential improvements in donor heart preservation, enhancing transplant success rates.

Abstract