Does low dose colchicine reduce left ventricular mass index in patients with coronary artery disease?
Patients with coronary artery disease
Low dose colchicine
Placebo
Left ventricular mass index (LVMI) reduction at 48 weekssurrogate
Low dose colchicine failed to demonstrate a reduction in left ventricular mass index compared to placebo at 48 weeks in an underpowered study of patients with coronary artery disease.
The study failed to demonstrate a treatment benefit of colchicine over placebo regarding LVMI reduction at 48 weeks. Given the early termination of the study, the results are inconclusive as the study was underpowered to detect small but potentially clinically meaningful differences.
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Ply Chichareon
Ruedeekorn Suwannanon
Metus Thungthienthong
British Journal of Clinical Pharmacology
Siriraj Hospital
Prince of Songkla University
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Chichareon et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69a75bb2c6e9836116a2382d — DOI: https://doi.org/10.1002/bcp.70470