March 3, 2026Open Access

GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

Key Points

Enhanced apoptosis occurs from anabasine release in mitochondria, driving synergistic effects against tumors.
The GSH-triggered mechanism allows for targeted drug delivery via OATP transportation in tumor cells.
Therapeutic effects are driven by ferritinophagy, indicating mitochondrial engagement in the treatment process.
This approach highlights potential for improving chemotherapy outcomes by combining prodrugs with mitochondrial targeting.

Abstract

• A GSH-triggered prodrug targeting tumor cell mitochondria via OATP-mediated uptake. • Release of a parent drug through an GSH-triggered S N Ar mechanism. • Translation of a nicotinic acetylcholine receptor to an antitumor drug. • Anabasine in mitochondria and induce a synergistic ferritinophagy and apoptosis.

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Discussion

Authors

Miao Zhang

Ling-Li Wang

Si-Ling Chen

Journals

Journal of Pharmaceutical Analysis

Actions

Institutions

Jilin University

First Hospital of Jilin University

Yanbian University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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