Complications of Primary Hyperparathyroidism: A Retrospective Study of 83 Cases

Abstract Introduction: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, characterized by inappropriate secretion of parathyroid hormone (PTH), leading to disturbances in calcium–phosphate metabolism and multisystem complications. Objective: To determine the prevalence and profile of clinical, biological, and radiological complications of PHPT in a Moroccan hospital-based cohort. Materials and Methods: We conducted a retrospective descriptive study including 83 patients with PHPT, followed between 2015 and 2022 in two university hospitals in Rabat. Clinical, biochemical, radiological, and bone densitometry data were analyzed. Results: The mean age was 53.27 years (range: 11–85 years), with a marked female predominance (90.4%). Skeletal manifestations were the most frequent (56.6%), followed by digestive (15.7%), urinary (10.8%), and cardiovascular manifestations (10.8%). Skeletal complications were observed in 48.2% of patients, including fractures (14.5%) and brown tumors (9.6%). Osteoporosis was identified in 33.7% of cases. Conclusion: Complications of PHPT remain frequent and severe, reflecting delayed diagnosis in our setting. Early detection and appropriate management could significantly reduce associated morbidity.