Transmural Healing is Associated With Higher Biological Drug Concentrations than Mucosal Healing in Crohn Disease

Key Points

• Transmural healing is associated with higher biological drug concentrations compared to mucosal healing, indicating a potential treatment differentiation.
• The study suggests that targeting transmural healing may improve treatment outcomes for Crohn disease patients on biological drugs, with implications for therapeutic strategies.
• Investigation of dose escalation in patients with mucosal healing may be beneficial to encourage transmural healing, potentially enhancing treatment efficacy.
• Ongoing clinical trials may help establish the cost-effectiveness of a treat-to-transmural-healing approach in managing Crohn disease.

Abstract