March 3, 2026Open Access

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Key Points

Leukaemogenesis is driven by DNTTIP1 through MiDAC-mediated epigenetic silencing of BMF, leading to cell death inhibition.
DNTTIP1 is notably overexpressed in acute leukaemia patients, correlating with a poorer prognosis.
Pharmacological disruption of the DNTTIP1-HDAC1/2-BMF axis effectively impairs leukaemogenesis, providing potential treatment avenues.
Epigenetic alterations in this pathway highlight significant therapeutic targets for future studies in acute leukaemia.

Abstract

DNTTIP1 is overexpressed in acute leukaemia and associated with poor prognosis. DNTTIP1 acts as a scaffold for the MiDAC complex, recruiting HDAC1/2 to silence BMF and inhibit leukaemic cell death. Pharmacological disruption of the DNTTIP1-HDAC1/2-BMF axis impairs leukaemogenesis.

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Cite this study

Xiu et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69a75bdcc6e9836116a23f05 — DOI: https://doi.org/10.1002/ctm2.70603

Authors

Ruolin Xiu

Yuzhu Ma

Si Li

Journals

Clinical and Translational Medicine

Actions

Institutions

Harbin Medical University

Qilu Hospital of Shandong University

First Affiliated Hospital of Harbin Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion