Exclusions affect representativeness of Alzheimer's disease trial participants

Key Points

• Ineligibility affects 74.2% of potential participants, raising concerns about generalizability.
• The most common reason for exclusion was cardiovascular conditions, impacting participant diversity.
• Analysis of 2742 participants reveals links between ineligibility and factors like age and body mass index.
• These findings highlight the need for broader inclusion criteria to improve representativeness in trials.

Abstract