Cultured muscle tissues have been integrated with artificial structures to construct biohybrid robots capable of diverse soft movements. However, most existing designs depend on artificial skeletons, limiting their flexibility and biomimetic potential. In this study, we propose a jointless, tongue‐like bioactuator composed entirely of skeletal muscle tissues. Inspired by the human tongue's multidirectional muscle architecture, vertically and horizontally aligned muscle tissues were assembled orthogonally. By exploiting the anisotropic responsiveness of muscle to directional electrical stimulation, the actuator exhibited distinct multidirectional motion patterns—swinging and lateral compression under horizontal stimulation, and swinging with enhanced linear contraction under vertical stimulation. Motion trajectory analysis confirmed that these multiaxis movements could be precisely controlled by tuning the direction and strength of stimulation. These results demonstrate that the configuration of orthogonally aligned muscle tissues can drive versatile multidirectional motion without rigid frameworks, providing a fully biological and biomimetic approach for achieving complex, multidegree‐of‐freedom actuation in muscle‐based biohybrid systems.
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Gao et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69a75bedc6e9836116a24253 — DOI: https://doi.org/10.1002/aisy.202501213
Xiang Gao
Kouhei Okasaki
Hirono Ohashi
Advanced Intelligent Systems
Waseda University
Tokyo University of Agriculture
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