Hyperglycemia differentially regulates osteoblast and osteoclast autophagy via AMPK/mTOR/p70 S6K signaling in diabetic osteoporosis

Puntos clave

• Increased hyperglycemia negatively impacts osteoblast autophagy, affecting bone formation.
• Osteoclast autophagy is also disrupted by hyperglycemia, leading to increased bone resorption.
• Analysis identifies AMPK/mTOR/p70 S6K as critical signaling pathways in this regulation.
• Targeting these pathways may present new therapeutic strategies for diabetic osteoporosis.