Quercetin and Curcumin’s Potential Defenses Against Rotenone-inducedParkinson’s disease in Rats

Introduction: Motor and behavioral impairments associated with Parkinson's disease (PD). The primary factors underlying the development of Parkinson's disease include mitochondrial impairment, increased oxidative stress, and the production of Lewy bodies due to protein misfolding. Antioxidants could help parkinsonism's symptoms get better and postpone neurodegeneration. We investigated the neuroprotective effects of curcumin, quercetin, and their combination in a rotenone-induced parkinsonism model. Methods: Rats given rotenone 2 mg/kg/day for 14 days developed PD. Doses were selected based on preliminary work. Oral administrations of curcumin (100, 150, and 200 mg/kg), quercetin (30, 40, and 50 mg/kg), or their combination were administered simultaneously with rotenone and continued for a further 14 days. Histological studies as well as tests for assessment of locomotor activity, rota rod test (muscular coordination), Grid test and Open-field test were performed. on the 28th and 29th days. Results: The higher doses of the used drugs; curcumin (200 mg/kg) and quercetin (50 mg/kg) enhanced locomotor activity, motor coordination, and mobility better than the lower doses. Furthermore, theysignicantly raised dopamine levels and helped minimize rotenone's produced neuronal damage. Discussion: In this study, against parkinsonism both quercetin and curcumin exhibit neuroprotective properties. Conclusion: Curcumin and quercetin used together has more positive results than each medicine taken by itself.